Нов медикамент за лечение на ХИВ - Triumeq, разрешен за употреба в Европа

На 3 септември 2014 г. Европейската комисия издаде разрешение за употреба за препарата Triumeq (dolutegravir50 мг/ abacavir 600 мг/ lamivudine 300 мг) под формата на таблетки за лечение на ХИВ при възрастни и подрастващи на възраст 12 и повече години, с минимално тегло 40 кг. 

Triumeq е комбиниран препарат, съдържащ интегразния инхибитор dolutegravir и два нуклеозидни инхибитора на обратната транскриптаза - abacavir и lamivudine.

Препоръчителната доза на Triumeq при възрастни е една таблетка дневно, приемана през устата със или без храна.

Triumeq не се препоръчва за употреба при пациенти с настояща или с история за резистентност към някоя от съставките на Triumeq. Освен това, Triumeq не се препоръчва и при пациенти с мутации, водещи до резистентност към интегразни инхибитори, или при клинични съмнения относно такава резистентност, защото дозата на dolutegravir в състава на Triumeq се явява недостатъчна при тях. Преди започване на лечение с препарати, съдържащи abacavir, при всички ХИВ-позитивни трябва да се направи скрининг за наличието на HLA B*5701. Abacavir не трябва да се прилага при пациенти, за които се знае, че са носители на HLA B*5701. Носителите на този генетичен маркер са изложени на висок риск от развитие на реакция на свръхчувствителност към abacavir.

Triumeq бе разрешен за употреба в САЩ от Американската агенция за храните и лекарствата на 22 август 2014 г. Интегразният инхибитор dolutegravir получи разрешение за употреба като самостоятелен препарат в САЩ през август 2013 г., а в Европа – през януари 2014 г. под търговското наименование Tivicay.

Източник: http://www.aidsbg.info

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Публикувана от rosen -четвъртък, 18 септември 2014 - 04:12:13изглед за печат

Cats lend a helping paw in search for anti-HIV drugs

If you're not making regular trips to the vet for your kitty these days, you may not know that cats can get AIDS too. 

The feline virus FIV that causes the disease in cats looks a lot like HIV, a fact that Technion scientists say could inspire new anti-HIV drugs.

How can a cat help the fight against AIDS? Both FIV and HIV rely on a protein called integrase that inserts the virus' DNA into an infected cell's DNA. Now, Assistant Professor Akram Alian and graduate student Meytal Galilee of the Technion-Israel Institute of Technology may have found a new weak point in the protein that drug designers may be able to target in the future.

In an article published online in Cell Structure, the two researchers from the Faculty of Biology offer up a detailed, 3-D molecular map of FIV integrase that could help scientists also understand how this protein works in HIV.

For instance, the researchers have pinpointed a single amino acid change that seems to be critical in highlighting how the protein assembles itself from simpler building blocks. Anti-HIV drug designers are eager to find ways to derail this assembly process.

Source: American Technion Society

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Публикувана от rosen -вторник, 16 септември 2014 - 12:45:23изглед за печат

Tackling homophobia - together

We’re bringing together MPs, civil society, the private sector and the trade union movement to collectively respond to the criminalisation of homosexuality.

At the Labour Party Conference on 23 September 2014, a panel will discuss how a cross-sector response should take shape in the UK to help to promote equality and support LGBT people in the 70+ countries worldwide where homosexuality is criminalised. Punishments around the world include life imprisonment, flogging and the death penalty.

Frank Mugisha, Executive Director of Sexual Minorities Uganda and the winner of the Robert F. Kennedy Human Rights Award is one of the panellists. Mugisha talks about how “legislating for hatred has distracted Ugandans and reversed hard-won gains in the fight against AIDS” in his essay for the inaugural edition of AIDS Today, which will be published this Autumn.

RecommendationsWe’ve detailed 8 points which we believe could effectively contribute to a cross-sector response, in our policy briefingChallenging criminalisation of LGBT people: Recommendations for governments, multilaterals, companies and NGOswhich you can read in full here.

The recommendations include ensuring there is a long term strategy that amplifies the voices of LGBT organisations in the countries affected by homophobic legislation, and provides the required investments in these community organisations.

We also call for consequences for governments or individuals that incite hatred or violate LGBT people’s rights, and call for an emergency funding mechanism to ensure vital support can reach LGBT people in danger during crisis periods.

Source: http://www.aidsalliance.org

Публикувана от rosen -сряда, 10 септември 2014 - 11:00:49изглед за печат

Delighted to be part of USAID & PEPFAR 'AIDSFree' Project

Strengthening High Impact Interventions for an AIDS-Free Generation (AIDSFree) is a new project to be led by JSI Research & Training Institute, Inc. (JSI).

he Alliance is one of a number of project consortium partners who will be part of efforts to provide global technical leadership, knowledge management, and capacity development support to governments and civil society in implementing evidence-based HIV and AIDS programs.

The overall goal of the AIDSFree project is to improve the quality and effectiveness of high-impact, evidence-based HIV and AIDS interventions to meet country-specific goals and objectives across the developing world.

Jason Wright, U.S. Director of the Alliance said: “We are delighted to be part of the AIDSFree project, which will allow us to draw on our extensive experience of building knowledge, mobilising people, inspiring leadership and allowing all voices to play significant roles in the local, national and global response to HIV.

Source: http://www.aidsalliance.org

Публикувана от rosen -понеделник, 08 септември 2014 - 10:57:55изглед за печат

Difficult Decisions: new tool for support workers

The Coalition for Children Affected by AIDS, which the Alliance is a member of, has launched a tool called ‘Difficult Decisions’.

t is designed for care workers to use when faced with an ethical dilemma in their work with children and families of key populations, such as people living with HIV, sex workers or people who use drugs.

The Coalition worked with key population networks and community-based organisations to test and improve the tool in four languages and five countries, Alliance Linking Organisations, the Malaysian AIDS Council (MAC)and Alliance Ukraine were two of the organisations that inputted.

You can download the tool from www.careworkerethics.org 

It includes example dilemmas and how they were resolved, a code of ethics, standalone worksheets, video clips, and ‘orientation slides’ to help people deliver a 3-hour orientation to their colleagues.

Source: http://www.aidsalliance.org

Публикувана от rosen -понеделник, 08 септември 2014 - 10:54:26изглед за печат

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